The present invention provides a multimeric form of a Tie 2 binding peptidemonomer, wherein the multimeric formhas Tie 2 agonist activity. The multimeric form, preferably a tetramer,stimulates angiogenesis and promotes wound healing. Thepresent invention also features pharmaceutical compositions comprising themultimeric Tie 2 agonists, including those suitable fortopical or systemic administration. Methods of using the multimeric Tie 2agonists of the invention for stimulating angiogenesis andfor promoting healing of wounds, such as diabetic ulcers or skin grafts, arealso provided.
