The present invention is a personal hand-held monitor with a signal acquisition device that acquires a signal that can be used to derive a measure of the health-related parameter of the user (PHHM), signal acquisition device , and one or more light emitters to deliver light to the body site of a user, and one or more light detectors for detecting light scattered by or human body region is transmitted through the human body region, two or more comprising a blood optical sensor having an optical cell, at least one of the optical cell, either containing an analyte to be detected, or mimic the absorption spectrum of the analyte, it is either or transmitted has been transmitted through the human body region, or light to or scattered scattered by the body site through the optical cell before reaching the photodetector, the processor of PHHM processes the signal received from the light detector or the light detectors, the sample cell or a light transmitted through each sample cell, the difference in intensity between the light transmitted through the non-analyte cell or each non-analyte cell was calculated to identify the pulse of the user, and a signal obtained from the optical sensor of the user pulse is configured to correlate to, PHHM is, in use, the arteries in the human body sites, as changes in the open from the closed during each pulse, put pressure on the PHHM to human body parts or apply pressure, or by the body site configured as a processor of PHHM derives a measure of the change in lumen area of the artery in each pulse, and the signal received from the blood photosensor, the change in lumen area of the pulse and arterial correlating configured to provide a measure of the concentration of analyte in the arterial blood, providing personal handheld monitor (PHHM).本発明は、ユーザの健康に関連するパラメータの測定値を導出するために使用することができる信号を取得する信号取得装置を備える個人ハンドヘルドモニタ(PHHM)であって、信号取得装置は、ユーザの人体部位に光を届ける1つまたは複数の光エミッタと、人体部位を通して伝達されるか又は人体部位で散乱される光を検出する1つまたは複数の光検出器と、2つ以上の光学セルとを有する血液光センサを備え、光学セルのうちの少なくとも
