Olivier Alexandre Laurent;Abhijit Suresh Bhat;Curt William Bradshaw;David Tumelty;Lauren Diane Wood;Alice Lee;Richard Ryan Preston;Wei Hong Yu
发明人:
Abhijit Suresh Bhat,Curt William Bradshaw,Olivier Alexandre Laurent,Alice Lee,Richard Ryan Preston,David Tumelty,Lauren Diane Wood,Wei Hong Yu
申请号：
US13305354
公开号：
US20120201809A1
申请日:
2011.11.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K188 according to Kabat numbering； a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.The invention further provides specific MAC compounds and compositions of the invention.
