Geert Feye Woerlee,Gerard Willem Hofland,Pieter Sebastiaan Vermeulen
申请号：
US12063680
公开号：
US08226984B2
申请日:
2006.08.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A process for the preparation of encapsulates, employs: a pumpable emulsion having (i) a continuous phase containing a solvent and a matrix-forming solute dissolved in the solvent and (ii) a dispersed phase an extractant including supercritical, subcritical or liquefied gas the solvent being substantially more soluble in the extractant than the matrix-forming solute and the process including the successive steps of: a) combining the pumpable emulsion with the extractant under mixing conditions b) allowing the formation of particulate encapsulates in which the dispersed phase is encased in a solid matrix of the matrix-forming solute c) collecting the encapsulates and separating them from the extractant. The present processes is particularly suitable for producing particles containing active ingredients that are very sensitive, whose activity is adversely affected by exposure to oxygen, light, moisture, heat and/or friction.
