A deep convolutional neural network can be trained to provide a patient radiation treatment plan. Training can include collecting patient data based on at least one image of patient anatomy from patients, determining a treatment plan including a set of control points from the collected patient data, and using the determined treatment plans and the corresponding collected patient data to train a deep convolutional neural network for regression to determine a treatment plan including a set of control points from collected patient data. The trained model can be used to provide a radiation treatment plan, such as in real-time.