PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which expresses treatment synergism in treatments of neoplastic disease.SOLUTION: This invention is a combination of a VEGF inhibitor (VEGF trap) which is an inhibitor of vascular endothelial growth factor and an irinotecan which is a topoisomerase inhibitor useful for treatment of known neoplastic disease, and is particularly aimed at the treatment of colorectal cancer or gastric cancer. The VEGF Trap used in the invention is a fusion protein comprising the signal sequence of VEGFR1 fused to the D2 Ig domain of the VEGFR1 receptor.【課題】腫瘍性疾患の処置にて治療相乗作用を示す医薬組成物の提供。【解決手段】血管内皮増殖因子の阻害剤である、VEGF阻害剤(VEGFトラップ)と既知の腫瘍性疾患の処置に有用なトポイソメラーゼ阻害剤であるイリノテカンの組み合わせであって、特に大腸癌または胃癌の処置を対象とする。VEGFトラップは、VEGFR1レセプターのD2Igドメインに融合したVEGFR1のシグナル配列を含む融合タンパク質である。【選択図】なし