A method for producing an artificial sebum film is provided with in raw material component and relative ratio, 78.4%-2% of triglyceride, 1%-15% of wax and ester, 20%-35% of squalane, 0.1%-7% of free fatty acid, 0.1%-6% of phospholipid, 0.1%-10% of cholesterol ester, 0.1%-10% of cholesterol, 0.1%-10% of antioxidant and 0.1%-5% of cellular activity regulator. The invention modifies the proportion of raw material composition of the artificial sebum film to reduce the negative effect generated by oxidation, and increase the proportion of squalane, so that the skin under high pollution can restore to the normal equilibrium state. Further, antioxidants and cellular active regulators are added to prolong the oxidation time of artificial sebum film and replenish the adenosine triphosphate in the cells.