1,2,4-oxadiazole derivatives as immunomodulators

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专利权人:

Aurigene Discovery Technologies Limited

发明人:

Sasikumar, Pottayil Govindan Nair,Ramachandra, Muralidhara,Naremaddepalli, Seetharamaiah Setty Sudarshan

申请号：

AU2014316682

公开号：

AU2014316682A1

申请日:

2014.09.05

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and 5 derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.

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中国工程科技知识中心

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