具有替代血液凝固第VIII因子之功能的多重專一性抗原結合分子农业专利-农业专业知识服务系统

发明人:: IGAWA, TOMOYUKI,井川智之,SAMPEI, ZENJIRO,三瓶全次郎,KOJIMA, TETSUO,小嶋哲郎,SOEDA, TETSUHIRO,添田哲弘,MUTO, ATSUSHI,武藤厚,KITAZAWA, TAKEHISA,北泽刚久,北澤剛久,NISHIDA, YUKIKO,西田由纪子,西田由紀子,IMAI, CHIFUMI,今

摘要：: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.本發明製作各種雙專一性抗體，其專一性地結合於血液凝固第IX因子/活化的血液凝固第IX因子及血液凝固第X因子兩者，且具有替代血液凝固第VIII因子之輔因子功能，亦即具有替代促進經活化的血液凝固第IX因子所為之使血液凝固第X因子活化之功能。該等抗體之中，成功發現替代血液凝固第VIII因子之功能的活性高的多重專一性抗原結合分子。