LOCKWOOD, SAMUEL FOURNIER,O'MALLEY, SEAN,WATUMULL, DAVID G.,HIX, LAURA M.,JACKSON, HENRY,NADOLSKI, GEOFF
申请号：
CA2495167
公开号：
CA2495167C
申请日:
2003.07.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A method for inhibiting and/or ameliorating the occurrence of diseasesassociated with reactive oxygen species, reactive nitrogen species, radicalsand/or non-radicals in a subject whereby a subject is administered acarotenoid structural analog, either alone or in combination with anothercarotenoid analog, or co-antioxidant formulation. The analog or analogcombination is administered such that the subject's risk of experiencingdiseases associated with reactive oxygen species, reactive nitrogen species,radicals and/or non-radicals may be thereby reduced. The analog or analogcombination may be administered to a subject for the inhibition and/oramelioration of ischemia-reperfusion injury. The analog or analog combinationmay be administered to a subject for the inhibition and/or amelioration ofliver disease. The analog or analog combination may be administered to asubject for the inhibition and/or amelioration of cancer. The analog or analogcombination may be administered to a subject for the inhibition and/oramelioration of cardiac arrhythmia and/or sudden cardiac death. The analog oranalog combination may be administered to a subject for the inhibition and/oramelioration of any disease that involves production of reactive oxygenspecies, reactive nitrogen species, radicals and/or non-radicals. In oneembodiment, a water-soluble and/or water-dispersible astaxanthin analog isparticularly effective. This invention further includes pharmaceuticalcompositions comprising structural carotenoid analogs either alone or incombination.
