Wound closure devices and methods of their use are described herein. A deployment instrument may be used to deploy and position tissue anchors which may be locked or secured along lengths of suture in suturing and plicating soft tissues, particularly along tissue regions located in areas of the body where space is limited. Generally, the fastening device may comprise a housing having one or more adjustable tissue anchors aligned longitudinally, wherein each of the one or more adjustable tissue anchors defines a receiving channel along a periphery of the tissue anchors, a tether having a length which is positionable within the receiving channel of each of the tissue anchors, and a plunger translatable relative to the housing, where movement of the plunger urges the one or more tissue anchors to attach securely to the tether.
