Spirocyclic compounds as inhibitors of serine proteases for the treatment of HCV infections

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

COTTRELL, KEVIN, M,MAXWELL, JOHN,TANG, QING,GRILLOT, ANNE-LAURE,LE TIRAN, ARNAUD,PEROLA, EMANUELE

申请号：

NZ57929608

公开号：

NZ579296A

申请日:

2008.02.27

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed are spiro compounds of formula (I), salts thereof, and methods for their preparation. A specific example of compounds of formula (I) is: 7-((S)-3-(benzo[b]thiophen-3-yl)-2-(2-cyclohexylacetamido)propanoyl)-3-(3-chlorophenyl)-N-((3R)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide, Compounds of formula (I) are useful for treating hepatitis C virus

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