SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.);SOCIETE DE CONSEILS DE RECHERCHES ET DAPPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
Benzimidazole and imidazo-pyridine derivatives (I) are new. Benzimidazole and imidazo-pyridine derivatives (I), their racemic and enantiomeric forms and their mixtures and their salts are new. [Image] A : CH 2, CO or C(O)C(R a)(R b)； X : C or N； R a, R bH or 1-6C alkyl； R 1, R 2H, 1-8C alkyl (optionally substituted by OH), 2-6C alkenyl or (CH 2) nX 1； X 13-7C cycloalkyl, heterocycloalkyl, aryl or heteroaryl (all optionally substituted by one or more halogen, NO 2, CN or (CH 2) n-V 1Y 1), 1-6C alkoxy or adamantyl； n : 0-6, such that when it is 0, then X 1 is neither OH nor alkoxy； or NR 1R 2heterobicycloalkyl or heterocycloalkyl (both optionally substituted by one or more S 1), 2,5-dihydro-1H-pyrrolo, 1,2,5,6-tetrahydropiperidino or a spirofused group of formula (a)； S 1OH, 1-6C alkyl, 1-6C hydroxyalkyl, 1-6C alkoxycarbonyl or C(O)NV 1'Y 1'； V 1', Y 1'H or 1-6C alkyl； R 3(CH 2) p-Z 3 or C(O)Z' 3； Z 31-6C alkyl, 2-6C alkenyl, 1-6C alkoxy, 1-6C alkoxy carbonyl, 3-7C cycloalkyl or heterocycloalkyl (both optionally substituted by 1-6C alkyl), aryl (optionally substituted by one or more halogen, azido, NO 2 or (CH 2) pV 3Y 3), heteroaryl or a bicyclic group of formula (b) or (c)； r : 1 or 2； V 3O, S, C(O), C(O)O, NHC(O), C(O)NR' 3, NHC(O)NR' 3 or a bond； Z' 3aryl (optionally substituted by one or more halogen, NO 2 or (CH 2) pV' 3Y' 3)； V' 3O, C(O), C(O)O, C(O)NR' 3, NHC(O)NR' 3 or a bond； Y 3, Y' 3H or 1-6C alkyl (optionally substituted by one or more halogen)； R' 3H, 1-6C alkyl or 1-6C alkoxy； R 4(CH 2) sR' 4； R' 4heterocycloalkyl containing at least one N (optionally substituted by 1-6C alkyl or aralkyl), heteroaryl containing at least one N (optionally substituted by 1-6C alkyl) or NW 4W' 4； W 4H or 1-8C alkyl； W' 4(CH 2) s'-Z 4； Z 4H, 1-8C alkyl (optionally substituted by one or more SZ 4), 2-6C alkenyl, 3-7C cycloalkyl (optionally substituted by one or more 1-6C alkyl), cyclohexene, heteroaryl, aryl (optionally substituted by one or more S 4) or a group (b)； SZ 41-6
