An insertion device for inserting at least a portion of at least one piercing member of an insertion set through the skin of a patient, the insertion device comprising: a device housing to support the insertion device relative to the skin of the patient a carrier body slidably received within the device housing for movement between an advanced position and a retracted position, the carrier body includes a receiving structure to support the insertion set in a position with at least one piercing member oriented for insertion through the skin of the patient upon movement of the carrier body from the retracted position to the advanced position a driver operatively coupled between the device housing and the carrier body to move the carrier body from the retracted position toward the advanced position to place at least a portion of the at least one piercing member of the insertion set through the skin of the patient to install the insertion set to the patient and wherein the receiving structure of the carrier body is removable from the insertion set while maintaining the installation of the insertion set to the patient.