MELISSA JEAN CASTEEL,BEI LI,DIANA SPERGER,DIMITRIOS STEFANIDIS
申请号：
ARP140102858
公开号：
AR097159A1
申请日:
2014.07.30
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Claim 1: a composition comprising: (i) a bismesilato Salt of a compound of the formula (1), or a hydrate thereof, and (ii) at least a pharmaceutically acceptable vehicle.Claim 3: the composition of claim 1 or 2, where the Salt bismesilato is a Polymorph which has a pattern of x-ray diffraction Reflections that includes 2Q, Plus or minus 0.2 degrees 2Q, 7.7, y18,1 17.7 12.9.Claim 7: the composition of claim 6, wherein the metansulf u00f3nico acid, or an anion of the same, and the compound of the formula (1), of the same or a cation, are present in the composition in a molar ratio of acid metansulf u00f3nico or an anion of the same, The Compound In the formula (1) or a cation of between 2:1 and 3:1.Claim 12: Composition of claim 11, wherein said at least one pharmaceutically acceptable Polymer hydroxypropylmethylcellulose. 14: the composition of claim claim 13, wherein the compound of the formula (1), of the same or a cation and an anion metansulf u00f3nico acid, or the same, is provided within the polymer Matrix.Claim 15: the composition of any of claims 1 to 14, which also includes water. Claim 16: the composition of any of claims 1, 2 and 5 to 15, in which the composition is a Feeding solution for Spray Drying.Claim 20: the composition of any of claims 1 to 14 and 17 to 19, in which the composition is a tablet. Claim 22: the composition of claim 21, wherein one of said at least one diluent is mannitol.Claim 23: the composition of any of Claims 20 to 22, which also comprises any one or more of crospovidone poloxamer, Colloidal SILICON DIOXIDE, Magnesium Stearate and microcrystalline Cellulose.Claim 24: a method for producing a tablet, which comprises: a) forming a Powder Spray Drying from a Feeding Solution, where the Feeding Solution includes: (i) a compound of the formula (1) or a cation of the same； (ii) metansulf acid u00f3nico,Or an anion of the same； (iii) at least one acceptable vehicle in Veterinary Medicine； and (iv) Water； and (b) in the granular Dry Spra
