Hydrates and polymorphs of 4-[[(7Ｒ)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide, methods for the production thereof, and use thereof as medicaments

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专利权人:

发明人:

린츠 귄터,지거 페터,크레머 게르트 에프.,랄 베르너,헤르터 롤프,호프만 맛티아스,슈미트 롤프

申请号：

KR1020077005956

公开号：

KR1012218640000B1

申请日:

2005.08.11

申请国别(地区):

KR

年份:

2013

代理人:

摘要：

Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]Amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide: processes for preparing them and their use as pharmaceutical compositions with antiproliferative activity.본 발명은 4-[[(7R)-8-사이클로펜틸-7-에틸-5,6,7,8-테트라하이드로-5-메틸-6-옥소-2-프테리디닐]아미노]-3-메톡시-N-(1-메틸-4-피페리디닐)-벤즈아미드의 신규한 수화물 및 신규한 다형체, 이들의 제조방법 및 약제로서의 이들의 용도에 관한 것이다.

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