Mehmet Toner;Mustafa Korkut Uygun;Martin L. Yarmush;Sinem Perk;Maria-Louisa Izamis;Basak Elif Uygun;Robert Marius Bieganski;Osman Berk Usta;Timothy Antonie Berendsen
发明人:
Martin L. Yarmush,Mehmet Toner,Maria-Louisa Izamis,Timothy Antonie Berendsen,Robert Marius Bieganski,Osman Berk Usta,Basak Elif Uygun,Mustafa Korkut Uygun,Sinem Perk
申请号：
US13695459
公开号：
US20140030231A1
申请日:
2011.05.04
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.
