A deep vein thrombosis prevention garment includes a body having a central panel, a left side panel, and a right side panel formed with a number of attachment straps having an integral fastener, such as Velcro® brand hook and loop fasteners. The central panel is formed with a single air chamber containing a single expandable air bladder receiving air from a pump through a flexible air supply tube. The central panel, left side panel and right side panel are formed from a single material which does not require a skin-safe liner or other combination of materials. The single chamber with nested expandable bladder is attached to the central panel. A cover panel covers the chamber having an expandable bladder, and is attached along its perimeter to the central panel. The cover panel and the body are made from the same material which can be placed against a patients skin.