The present invention provides combination vaccines that comprise animmunological agent effective for reducing the incidence of or lessening theseverity of PPE caused by L. intracellulars, and one or more immunologicalactive components effective in treatment and/or prophylaxis of at least onefurther disease-causing organism for swine. Moreover, the present inventionalso relates to a kit that comprises an immunological agent effective forreducing the incidence of or lessening the severity of PPE caused by L.intracellularis, and one or more immunological active components effective intreatment and/or prophylaxis of at least one further disease-causing organismfor swine.