THE PRESENT INVENTION RELATES TO AT LEAST ONE NOVEL ANTI-DUAL INTEGRIN ANTIBODIES, INCLUDING ISOLATED NUCLEIC ACIDS THAT ENCODE AT LEAST ONE ANTI-DUAL INTEGRIN ANTIBODY, DUAL INTEGRIN, VECTORS, HOST CELLS, TRANSGENIC ANIMALS OR PLANTS, AND METHODS OF MAKING AND USING THEREOF, INCLUDING THERAPEUTIC COMPOSITIONS, METHODS AND DEVICES.