Carlos A. Ramos,Cliona M. Rooney,Sandhya Sharma,Benjamin Hyun Joon Shin,Alex Salyer
申请号：
US15885197
公开号：
US10500265B2
申请日:
2018.01.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.
