Claim 1: a cystine Knot Peptide (CKP) are not of Natural Origin that binds to vascular endothelial growth factor (VEGF), wherein the CKP includes Frame structure of cystine z u00b9c u00b9l u00b9c u00b2l u00b2c u00b3l u00b3c u2074l u2074c u2075l u2075c u2076z u00b2: and where are any z u00b9 z u00b2 am Ino u00e1cido； l u00b9 is the Loop 1 and has a structure selected from the group consisting of: x u00b9x u00b2x u00b3x u2074x u2075x u2076 (SEQ ID no. 2)X u00b9x u00b2x u00b3x u2074x u2075x u2076x u2077 (SEQ ID no. 3), x u00b9x u00b2x u00b3x u2074x u2075x u2076x u2077x u2078 (SEQ ID no. 4), x u00b9x u00b2x u00b3x u2074x u2075x u2076x u2077x u2078x u2079 (SEQ ID no. 5) and x u00b9x u00b2x u00b3x u2074x u2075x u2076x u2077x u2078x u2079x u00b9 u2070 (SEQ ID no. 6), where each of x u00b9 - x u00b9 u2070 is any amino acid； L u00b2 is the Loop 2 and has the structure: x u00b9x u00b2 X u00b3x u2074x u2075 (SEQ ID no. 7), where each of x u00b9 - x u2075 is any amino acid or a non natural amino acid； l u00b3 is the Loop 3 and has the structure: x u00b9x u00b2x u00b3,Each of x u00b9 - where X is any amino acid or a non natural amino acid； l u2074 is the Loop 4 and has the structure x u00b9 x u00b9: Where is any amino acid or a non natural amino acid； l u2075 is the Loop 5 and has the structure: x u00b9x u00b2x u00b3x u2074x u2075 (SEQ ID no. 7)Where each of x u00b9 - x u2075 is any amino acid or a non natural amino acid； where the non natural amino acid selected from the group consisting propargilglicina - L - peg u2086 sulfotirosina -, L -, L - - - naftilalanina Norleucine, L 1, L 2 - - - - clorotript u00f3fano naftilalanina, L 2, L 3 - fluorotirosina, L - 4 - F Luorofenilalanina, l-proline benzyl - G -, G - (4 - fluoro - benzyl) - l-proline, 4 - L - proline, 4 - fluoro - L - proline,4 - [4 - (trifluoromethyl) benzyl] - l-proline, 3,4 - difluoro - L - phenylalanine, 3,4 Dichloro - L - phenylalanine, 4-chloro - L - phenylalanine, 3 - 4 F -, CL - L - phenylalanine, 2 - piridona
