WOO YOUNG EUN,JANG MYUNG HYUN,PARK YOUNG JIN,PARK YOUNG KYUNG,LIM CHANG KI,KWON SE CHANG
申请号：
NZ61879312
公开号：
NZ618793A
申请日:
2012.06.01
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to a composition comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate wherein each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, polyoxyethylated polyol, polyvinyl alcohol, polysaccharide, dextran, polyvinyl ethyl ether, a biodegradable polymer, a lipid polymer, chitin, hyaluronic acid, and a combination thereof. The immunoglobulin Fc region may be an Fc region derived from IgG, IgA, IgD, IgE, or IgM. The disclosure also relates to the use of this composition for the prevention or treatment of diabetes.
