DELGADO GAÑÁN, Maria Isabel,SANAGUSTIN AQUILUE, Javier,LENDÍNEZ GRIS, María Del Carmen
申请号：
CR20200024
公开号：
CR20200024A
申请日:
2018.01.18
申请国别(地区):
CR
年份:
2020
代理人:
摘要：
It refers to the composition of an oil nanoemulsion on water, which has a continuous water phase and dispersed oil droplets, wherein the nanoemulsion includes: (a) clobesol； (b) one or more oil components； and (c) one or more surface active components； Together with one or more pre aspirator or drug acceptable vehicles: nanolatex permeability from 100 mOsm / kg to 500 mOsm / kg； average drop volume measured by PDS reduced from MFN to 500 nm； fuel composition to total weight ratio Oil ingredients and one or more surface active ingredients range from 0.001 to 0.5.The weight ratio of oil ingredients to clobesol varies from 1:1 to 200:1； the weight ratio of surface active ingredients to clobesol varies from 2:1 to 200:1. It also covers its preparation, use as a drug, and prevention and / or treatment procedures for diseases or diseases. Flammability. 2.Relates to an oil-in-water nanomiulsion composition having a continuous aqueous phase and dispersed oil droplets，when the nanomiulsion comprises：（a）Clobesol； （b）One or more oil components；and（c）one or more surfactants；1.Together with one or more pharmaceutically acceptable excipients or carriers where rein:the osmolability of the nanomilsion is comprised from 100 mosm/kg to 500 mosm/kg；the droplet average size measured by dynamic light scattering is comprised from 1 nm to 500 nm；the weight ratio between the oil components and the sum of the oil components and one Or more surfactants is comprised from 0.001 to 0.5；the weight ratio between the oil component and clobetasol is comprised from 1:1 to 200:1；and the weight ratio between the surfactant and clobetasol is comprised from 2:1 to 200:1. IT also relates to processes for its preparation，its use as a medical，and in the prophylaxis and/or treatment of inflammatory diseases or conditions.Se refiere a una composición de nanoemulsión de aceite en agua que tiene una fase acuosa continua y gotas de aceite dispersas, en donde la nanoemulsión comprende: (a) clobetasol； (b) uno o
