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GABA A Composition for improving preventing or treating sleep disorders or composition for inhibitiong resistance or reducing side effects of GABA A receptor agonist comprising phloroglucinol as an effective ingredient
专利权人:
KOREA FOOD RESEARCH INSTITUTE
发明人:
CHO, SUENG MOK,조승목,UM, MIN YOUNG,엄민영,YOON, MIN SEOK,윤민석,YANG, HYE JIN,양혜진,LEE, JAE KWANG,이재광,JUNG, JONG HOON,정종훈,CHO, SUENG MOKKR,UM, MIN YOUNGKR,YOON, MIN SEOKKR,YANG, HYE JINKR,LEE, JAE KWANGKR,JUNG, JONG HOONKR
申请号:
KR1020170058387
公开号:
KR1018995460000B1
申请日:
2017.05.11
申请国别(地区):
KR
年份:
2018
代理人:
摘要:
The present invention relates to a pharmaceutical composition containing phloroglucinol as an effective component for preventing or treating sleep disorders, or a functional health food composition for improving sleep disorders, capable of preventing a user from repeatedly wakening while inducing the user to sleep quickly and reliably, avoiding a change in the physiological sleeping structure, avoiding remaining sedation causing incomplete daytime activity or recognition performance, preventing tolerance caused by long-period medication, and preventing side effects of a conventional GABAA receptor agonist. Moreover, a pharmaceutical composition containing phloroglucinol as an effective component for suppressing the tolerance of a GABAA receptor agonist or reducing side effects of the same, or a functional health food composition for suppressing the tolerance of a GABAA receptor agonist or improving side effects of the same is capable of reducing side effects of a GABAA receptor agonist or suppressing tolerance caused by the long-period use of a GABAA receptor agonist. Moreover, a pharmaceutical composition containing phloroglucinol and a GABAA receptor agonist as effective components for preventing or treating sleep disorders is capable of reducing the content of a GABAA receptor agonist causing various side effects such as increasing the amount of sleep or degrading sleep quality, thereby relieving side effects of a GABAA receptor agonist or suppressing tolerance caused by the long-period medication of a GABAA receptor agonist.본 발명의 플로로글루시놀을 유효성분으로 하는 수면 장애 예방 또는 치료용 약학 조성물, 또는 수면 장애 개선용 건강기능식품 조성물은 빠르고 신뢰성 있게 수면을 유도하거나 유지시키면서, 반복적인 잠깸 증상을 방지할 수 있고, 생리적인 수면 구조를 변경시키지 않으며, 특히 불완전한 주간 활동이나 인식 능력을 야기할 수 있는 잔류 진정 작용이 없고, 장기간 투여에 의해서도 내성이 발생하지 않고, 종래 GABAA 수용체 효능제의 부작용이 발생하지 않는다.또한 본 발명의 플로로글루시놀을 유효성분으로 하는 GABAA 수용체 효능제의 내성 억제 또는 부작용 경감용 약학 조성물, 또는 GABAA 수용체 효능제의 내성 억제 또는 부작용 개선용 건강기능식품 조성물은 GABAA 수용체 효능제의 부작용을 경감시키거나 GABAA 수용체 효능제의 장기 투여에 따른 내성을 억제할 수 있다.또한 본 발명의 플
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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