CHANG, CHIEN-HSING,GOLDENBERG, DAVID M.,LIU, DONGLIN
申请号：
CA2861335
公开号：
CA2861335A1
申请日:
2013.01.25
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention concerns methods and compositions for forming complexes of interferon-? with an antibody or antigen-binding antibody fragment. In preferred embodiments, the interferon-? and the antibody or fragment are fusion proteins, each comprising a dimerization and docking domain (DDD) moiety from human protein kinase A or an anchor domain (AD) moiety from an A-kinase anchoring protein (AKAP). In more preferred embodiments, the interferon-antibody complex is more efficacious for treatment of cancer, asthma, Alzheimer's disease, multiple sclerosis or viral infection than interferon-? alone, antibody alone, or the combination of unconjugated interferon-? and antibody.
