The present invention relates to antidotes of anticoagulants targeting factorXa which antidotes are used incombi-nation with blood coagulating agents or other heparin antidotes toprevent or reduce bleeding in a subject. The antidotes describedherein have reduced or no intrinsic coagulant activity. Disclosed herein aremethods of stopping or preventing bleeding in apa-tient that is or will be undergoing anticoagulant therapy with a factor Xainhibitor.