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Inhibitors of beta integrin-G protein alpha subunit binding interactions
专利权人:
发明人:
Xiaoping Du
申请号:
US14176930
公开号:
US09156884B2
申请日:
2014.02.10
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Provided herein are compounds that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
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