An isoacteoside derivative and forming method and uses thereof； the isoacteoside derivative has a structure of formula (I):R1 and R2 are independently selected from hydrogen, halogen, hydroxyl and alkoxy oxyl； R3 and R4 are independently selected from hydroxyl, alkoxy oxyl and acyloxy； R5 is independently selected from hydroxyl or acyloxy. Drugs comprsing the isoacteoside derivative have uses of treating or preventing amyloid peptide related diseases and preventing eye lesions and the like.
