Marc D. Friedman,Pavel Kamaev,Martin Joseph Coffee,Rajesh K. Rajpal,Alexandra Nicklin
申请号：
US15901496
公开号：
US20180236077A1
申请日:
2018.02.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Formulations, are used for eye treatments, e.g., cross-linking treatments. For example, a therapeutic formulation includes a photosensitizer and delivery agent(s), wherein the delivery agent(s) include at least one of: anesthetic agent(s), analgesic agent(s), tonicity agent(s), or shear-thinning, or viscosity-increasing agent(s). In another example, a method includes applying preparatory formulation(s) to increase a permeability of a corneal epithelium, and applying therapeutic formulation(s) to the epithelium, where the preparatory formulation(s) include zinc metalloproteinase, copper metalloproteinase, papain, bromelain, actinidin, ficain, N-acetylcysteine, ambroxol, carbocisteine, and/or erdosteine. In yet another example, a method includes applying therapeutic formulation(s) to a corneal epithelium to deliver the therapeutic formulation(s) to a stroma, and applying enhancement formulation(s) to the epithelium in response to applying the therapeutic formulation(s), where: the enhancement formulation(s) remove the therapeutic formulation(s) from the epithelium； close tight junctions of the epithelium； promote oxidation for the therapeutic agent(s)； and/or further deliver the therapeutic formulation(s) to the stroma.
