The present invention provides a novel phillygenin glucuronic acid derivative shown as a general formula (I).wherein, R1=H, R2=CnH2n+1, R3=CnH2n+1 or R1=CnH2n+1, R2=CnH2n+1, R3=H or R1-R2=-CH2-, R3=CnH2n+1; n=1-30. The present invention further relates to a preparation method of the compound, a pharmaceutical composition taking the compound as an active ingredient, as well as application of the compound in the present invention in antiviral diseases.