Problem to be solved: to provide an anti-HER2 antibody and an immune complex and use thereof.An isolation antibody that binds HER2;Hvr-h1 containing specific amino acid sequences(b) hvr-h2 containing specific amino acid sequences(c) hvr-h3 containing specific amino acid sequences(d) hvr-l1 containing specific amino acid sequences(E) hvr-l2 containing specific amino acid sequences(f) hvr-l3 containing specific amino acid sequencesIncludingSaid isolated antibody.Diagram【課題】抗HER2抗体及び免疫複合体、ならびにそれらの使用方法を提供する。【解決手段】HER2に結合する単離抗体であって、特定のアミノ酸配列を含むHVR-H1と、(b)特定のアミノ酸配列を含むHVR-H2と、(c)特定のアミノ酸配列を含むHVR-H3と、(d)特定のアミノ酸配列を含むHVR-L1と、(e)特定のアミノ酸配列を含むHVR-L2と、(f)特定のアミノ酸配列を含むHVR-L3と、を含む、前記単離抗体。【選択図】図3