COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DES MALADIES VASCULAIRES PÉRIPHÉRIQUES UTILISANT LE FACTEUR DE CROISSANCE DES HÉPATOCYTES ET LE FACTEUR 1A DÉRIVÉ DES CELLULES STROMALES
The present invention relates to a pharmaceutical composition for preventing or treating peripheral vascular disease, the composition comprising, as an active ingredient: (a) hepatocyte growth factor (HGF) or an isoform thereof, and stromal cell derived factor 1± (SDF-1±)； or (b) a polynucleotide encoding the HGF and a polynucleotide encoding the SDF-1±. The peripheral vascular disease (for example, ischemic limb disease) can be more effectively prevented or treated through the significant promotion of vascular endothelial cell migration and angiogenesis in the case of singly using the composition of the present invention than in the case of using HGF, an isoform thereof, SDF-1± or a polynucleotide codes a protein thereof.
