OLIGONUCLEOTIDE ANTISENS AYANT UNE TOXICITE REDUITE

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专利权人:

TOKYO INSTITUTE OF TECHNOLOGY;NISSAN CHEMICAL CORPORATION

发明人:

MASAKI, YOSHIAKI,SEIO, KOHJI,INOUE, ATSUSHI,IRIYAMA, YUSUKE,KANAKI, TATSURO,NAKAJIMA, HIROYUKI

申请号：

CA3094303

公开号：

CA3094303A1

申请日:

2019.03.20

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Provided is an antisense oligonucleotide having reduced toxicity. This antisense oligonucleotide has a central region, a 5'-side region, and a 3'-side region, and is characterized by having, in the central region: a nucleotide in which the 2'-position and 3'-position of the sugar moiety thereof are cross-linked (2'-3' cross-linked nucleotide)； and/or a non-cross-linked nucleotide having a substituent at position 3' thereof (position 3'-modified non-cross-linked nucleotide).

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中国工程科技知识中心

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http://www.ckcest.cn/home/