The present invention describes a system for inducing at least compressional or shear force on a subject and evaluating pain modulation, spatial and/or temporal summation of pain, or descending inhibition of pain in the subject, said system comprising a cuff unit comprising an inflatable cuff having at least two chambers or comprising at least two inflatable cuffs having one or more chambers each, each chamber having a coupling for connection to a compressor or other activator device a compressor or other activator device arranged to provide inflation and a computer unit with a control function, said control function directed to control of inflation rates and independent control of each chamber. The present invention is also directed to an inflatable cuff for a system according to above and also to the use and methods involving the use of such a system.
