NELSON, Jay,MALOULI, Daniel,PICKER, Louis,HANCOCK, Meaghan,SACHA, Jonah,FRUEH, Klaus,HANSEN, Scott
申请号：
PE2019000824
公开号：
PE20190840A1
申请日:
2017.10.18
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
There are CMV vehicles without active proteins of UL128, UL130, UL146 and UL147. These vehicles may also contain one or more regulatory elements of MicroARN (MRE), which limits the performance of CMV. By immunizing with exposed CMV vectors, different responses can be selected from different mobile phones, which are limited by mhc-ia, MHC-II or mhc-e.Se revelan vectores de CMV que carecen de proteinas UL128, UL130, UL146 y UL147 activas que tambien pueden comprender uno o mas elementos reguladores de microARN (MRE) que restringen la expresion del CMV. La inmunizacion con los vectores de CMV revelados permiten la seleccion de diferentes respuestas de las celulas T CD8+ - celulas T CD8+ restringidas por MHC-Ia, MHC-II, o MHC-E
