Chandra Vargeese,Meena,Nenad Svrzikapa,Susovan Mohapatra,Christopher J. Francis,Gregory L. Verdine,Anna Sokolovska
申请号：
US16098836
公开号：
US10724035B2
申请日:
2017.05.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.
