PROCESS FOR THE PREPARATION OF 2-(3-CYANO-4-ISOBUTYL-OXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID AND INTERMEDIATES THEREOF

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专利权人:

发明人:

DWIVEDI SHRIPRAKASH DHAR,PRASAD ASHOK,ROY RUSHIKESH UDAYKUMAR,DESAI AMAR RAJENDRA

申请号：

IN3026/MUM/2009

公开号：

IN2009MU03026A

申请日:

2009.12.30

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

The present invention relates to the process for the preparation of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, "Febuxostat" (1) and intermediates thereof. In particular the present invention relates to the process for the preparation of 3-(substituted-4,5-dihydrooxazol-2-yl)-4-isobutoxybenzothioamide (4) and its use for the preparation of Febuxostat (1). This compound has an action of regulating biosynthesis of uric acid in vivo and can be used as a therapeutic agent for hyperuricemia.

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