Devices and methods are provided for stabilizing fasteners post-deployment. In general, the devices and methods can allow fasteners to resist counter rotation after being deployed. A fastener can be configured to resist counter rotation in a variety of ways. In some embodiments, a staple can include one or more anti-rotation mechanisms configured to resist counter rotation of the staple when the staple is deployed in tissue. In some embodiments, an orientation of a fastener relative to an orientation of one or more fasteners deployed adjacent thereto can be configured to help prevent counter rotation.
