DR. SIEBENEICHER, HOLGER,DR. ANDRES, DOROTHEE,DR. SCHMIDT, NICOLE,DR. GNTHER, JUDITH,DR. BMER, ULF,DR. NUBBEMEYER, REINHARD,DR. BOTHE, ULRICH,RING, SVEN
申请号：
ARP170101476
公开号：
AR108642A1
申请日:
2017.05.31
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
1. The present request relates to alternative benzimidazole, used alone or in combination for the treatment and / or prevention of diseases, and for the production of drugs for the treatment and / or prevention of diseases, in particular for the treatment and / or prevention of endocrine, And endocrine related pain and other endocrine symptoms, such as demenorea, dispareunia, disuria and disquecia, lymphoma, rheumatoid arthritis, sporitis (especially psychosis and bechterw's disease),Systemic lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disease, insulin resistance, tumor diseases and psoriasis. Claim 1: Compounds of the general formula (1) characterized in that R¹ represents a 5- or 6-membered heteroaryl, which contains 1 or 2 identical or different heteroatoms selected from the group O, S and N and is linked by an annular carbon atom, where a 5-membered heteroaryl may be monosubstituted with C₃₋₆ cycloalkyl or C₁₋₃ alkyl,which can be substituted with halogen and where in the case that the 5-membered heteroaryl means pyrazolyl, pyrazolyl can be monosubstituted in N with C₃₋₆ cycloalkyl or C₁₋₃ alkyl,which may be substituted with halogen； and where a 6-membered heteroaryl may be mono- or disubstituted in the same or different manner with halogen, C₁₋₃ alkoxy,NH.8322；1. Apartment c83218331；which may be substituted with halogen； A represents a bond or C₁₋₆ alkyl；R2 in the case of lease c832131 / 832626,For hydrogen, alcoxi c8321c833123；S (= O) 832222 - lease c832183；NH (rent c832131)N (c833312118) 832222 or 4, 5 or 6 member heterocyclic electrolysis, which contains one or two identical or different heteromorphic atoms or heteromorphic groups selected from O, s (= O) 832222；N, NH, N (C₁₋₃ alkyl) and is linked either by an annular carbon atom or an annular nitrogen atom or R² in the event that A is a bond, represents C₁₋₆ alkyl,which may be monosubstituted with -OH, or represents a 5- or 6-membered heterocycloalkyl, which contai
