PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES CONTAINING THE AERIAL PARTS OF ORYZA SATIVA L. EXTRACTS, FRACTIONS, THE ISOLATED FLAVONOLIGNANS COMPOUNDS THEREFROM, OR THE PHARMACEUTICALLY ACCEPTABLE SALTS AS AN ACTIVE INGREDIENT
경희대학교 산학협력단;UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人:
BAEK, NAM IN,백남인,JEONG, RAK HUN,정락훈,LEE, DAE YOUNG,이대영,CHO, JIN GYEONG,조진경,KIM, JI YOUNG,김지영,KIM, SUNG HWAN,김성환
申请号：
KR1020100130143
公开号：
KR1020120089893A
申请日:
2010.12.17
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A pharmaceutical composition containing extract and fraction of an aerial part of Oryza sativa L. and flavonolignan compounds isolated from the same is provided to suppress NO generation and to reduce side effects. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory diseases contains extract of an aerial part of Oryza sativa L. as an active ingredient. The extract is prepared using 80% methanol solution. The pharmaceutical composition contains a fraction of an aerial part of Oryza sativa L. as an active ingredient. The fraction is prepared by extracting the extract using n-hexane and H_2O, extracting a H_2O layer using ethyl acetate, and extracting H_2O by n-butanol. The pharmaceutical composition contains flavonolignan compounds or pharmaceutically acceptable salt thereof as an active ingredient.본 발명은 벼 지상부 추출물, 벼 지상부 분획물, 이로부터 분리된 플라보노리그난 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 염증성 질환의 예방 및 치료용 약학적 조성물은 염증유발물질 중 하나인 NO(Nitric Oxide)에 대해 생성 억제 활성을 가짐으로써 종래의 염증성 질환 치료제에 비해 부작용을 현저히 감소시킬 수 있다.
