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DERIVATIVES OF AZA-ADAMANTANES AND THEIR APPLICATION
专利权人:
KONEKSHIS LAJF SAJENSIZ PVT. LTD.
发明人:
RAO Dzhagannat Madanakhalli Ranganat (IN),РАО Джаганнат Маданахалли Ранганат (IN),VENKATESHAM Uppala (IN),ВЕНКАТЕШАМ Уппала (IN),DOPPALAPUDI Sivanagesvara Rao (IN),ДОППАЛАПУДИ Сиванагесвара Рао (IN),K
申请号:
RU2014126647
公开号:
RU0002672468C1
申请日:
2012.12.21
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula (I),where: each R1, R1a and R2 is independently selected from the group consisting of H, halogen, OH, CN, CF3, OCF3, OCH3, CH2OH, C3cycloalkyloxy, COOH, CONR3R4 and tetrazole; Ar is a group of the following formula:,e is an integer selected from the group consisting of 0, 1, 2, 3 and 4; f e is an integer selected from the group consisting of 0, 1, 2 and 3; where each R8 is independently selected from the group consisting of H, halogen, methoxy, OCF3, OCF2H, isopropoxy, methyl, propyl, 4-fluorophenyl, thiophene, furan, 5-fluorofuran, 5-fluorothiophene, 5-chlorothiophene, 5-chlorofuran, OSO2CF3, OSO2CH3, cyclopropyl and cyclopropyloxy; where R9 is selected from the group consisting of H and methyl; A is -CRaRb-; B represents a group of the formula -(CRcRd)n-; where each Ra and Rb is independently selected from the group consisting of H, methyl, ethyl, isopropyl, cyclopropyl, phenyl, 4-chlorophenyl, 4-fluorophenyl and thiophen-2-yl; where Rc and Rb are both H; where each R3 and R4 is H, n is an integer selected from the group consisting of 0 and 1; a is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.EFFECT: compounds that are capable of inhibiting 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are useful in the treatment of conditions such as non-insulin-dependent diabetes mellitus type 2 (NIDDM), insulin resistance, obesity, dyslipidemia.20 cl, 1 tbl, 238 exИзобретение относится к соединениям формулы (I)где: каждый R1, R1a и R2 независимо выбран из группы, состоящей из Н, галогена, ОН, CN, CF3, OCF3, ОСН3, СН2ОН, С3циклоалкилокси, СООН, CONR3R4 и тетразола; Аr представляет собой группу следующей формулы:е представляет собой целое число, выбранное из группы, состоящей из 0, 1, 2, 3 и 4; f представляет собой целое число, выбранное из группы, состоящей из 0, 1, 2 и 3; где каждый R8 независимо выбран из группы, состоящей из Н, галогена, метокси, OCF3
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