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CYTOTOXICITY-INDUCING THERAPEUTIC AGENT
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
NEZU, Junichi,NARITA, Atsushi,ISHIGURO, Takahiro,SAKURAI, Mika,SHIRAIWA, Hirotake,HIRONIWA, Naoka,IGAWA, Tomoyuki,KAWAI, Yumiko
申请号:
PH12017500507
公开号:
PH12017500507A1
申请日:
2017.03.16
申请国别(地区):
PH
年份:
2017
代理人:
摘要:
A novel multispecific antigen-binding molecule, which comprises a domain containing an antibody variable region having an activity of binding to glypican 3 and a domain containing an antibody variable region having an activity to bind to a T cell receptor complex and retains excellent cytotoxic activity and high safety, was found. The molecule according to the present invention exhibits potent cytotoxic activity on cells and tissues expressing glypican 3 and, therefore, enables the production of new pharmaceutical compositions for treating or preventing various kinds of cancers.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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