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LUNG CANCER SPECIFIC PEPTIDES FOR TARGETED DRUG DELIVERY AND MOLECULAR IMAGING
专利权人:
发明人:
WU, HAN CHUNG,吴汉忠,吳漢忠,CHI, YI HSUAN,纪怡亘,紀怡亘
申请号:
TW104101564
公开号:
TWI578999B
申请日:
2015.01.16
申请国别(地区):
TW
年份:
2017
代理人:
摘要:
A conjugate is disclosed. The conjugate comprises (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1-8 and (b) a component conjugated to the targeting peptide, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, a liposome, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. Methods of treating lung cancer and detecting lung cancer cells are also disclosed.本發明係揭示一種共軛物。該共軛物包含:(a)小於15個胺基酸殘基長度之經分離或合成之標靶胜肽,其包含一與選自於由SEQ ID NOs:1-8組成群組之序列具有至少90%相同度之胺基酸序列;以及(b)共軛至該標靶胜肽上之組分,該組分選自於由藥物輸送載劑、抗癌藥物、微胞、奈米顆粒、微脂體、聚合物、脂質、寡核苷酸、胜肽、多肽、蛋白質、細胞、顯像劑、及標記劑組成之群組。本發明亦揭示一種治療肺癌及檢測肺癌細胞之方法。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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