SUBBA RAO POLIMERA,RAMESH KUMAR SISTLA,KANDHASAMY SARKUNAM,SREEKANTHA RATNA KUMAR,VENKATRAM REDDY PAIDI,SATHEESH KESAVAN NAIR,DURGARAO KANTHETI,HONG WU,JOSEPH B. SANTELLA,NATESSAN MURUGESAN,JOHN E. MA
申请号：
ARP160101891
公开号：
AR105112A1
申请日:
2016.06.23
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: a compound characterized by the formula (1) or a Salt that, where a heteroaryl: Het is selected oxazolilo, pirazolilo, imidazo [1,2-b] pyridazin-3 3 - ILO and pyrazolo [1,5-a] pyrimidine - 3 - ILO, where he joined the heteroaryl Group pyridinyl in con To the formula (1) by a carbon Atom in the Ring heteroaryl,And where the heteroaryl is replaced with 0 to 2 r u1d47； each r u1d47 is selected independently - H, F, CL, - CN, - nh u2082, c u2081 u208b u2083 c u2081 u208b u2082 fluoroalquilo, c u2081 u208b u2083 alkoxy alkyl, cycloalkyl, c u2083 u208b u2086, - NH (c u2081 u208b u2083 alkyl) - NH (c u2081 u208b u2084 hidroxialquilo pyridinyl), cianofenilo, e h Idroxipirrolidinilo； r u00b9 is (i) c u2083 u208b u2086 alkyl substituted with 1 to 4 substituents selected regardless of F, - CN, - Oh, - - och u2083, ocd u2083,(o) - NHC (c u2081 u208b u2083 alkyl) - S (o) u2082 (c u2081 u208b u2083 alkyl) and c u2081 u208b u2082 fluoroalcoxi； and (ii) - ( u2081 u208b u2083r u02e3 cr u02b8r u02b8) or - (ch u2082) u2081 u208b u2083c u208do u208er u02e3, where r u02e3 is phenyl, oxetanilo, tetrahidropiranilo, morfolinilo, piperidinilo, imidazolilo； c u2084 u208b u2086 pyridinyl, tiofenilo or cycloalkyl, each one Replaced with 0 to 3 substituents selected regardless of F, CL, Oh, c u2081 u208b u2083 alkylC u2081 u208b u2082 alkoxy and - S (o) u2082nh u2082； (iii) c u2084 u208b u2086 cycloalkyl substituted with substituents selected regardless of 0 to 2 - alkoxy - c u2081 u208b u2084 hidroxialquilo, c u2081 u208b u2083, (ch u2082) u2081 u208b u2083o (c u2081 u208b u2083 alkyl, - C (o) NH (c u2081 u208b u2084 alkyl, - C (o) NH (c u2083 u208b u2086 cycloalkyl) n - (c u2081 u2082, u208b u2083 alkyl) - NHC (OR) (c u2081 u208b u2083 alkyl) - NHC (OR) or (c u2081 u208b u2083 alkyl) and (OR) - NHC (c u2081 u208b u2084 hidroxialquilo)； (iv) tetrahidrofuranilo, tetrahidropiranilo, piperidinilo,Piperazinilo, pirrolilo, pirazolilo, imidazolilo or triazolilo each: One replaced with
