A device to prepare and administer a two-component mixture, including a first chamber in which a container is housed that is hermetically closed for a liquid component, a second chamber containing a powdered component, an opening of the container of the liquid component, a mixing member placed in the second chamber for preparing the mixture and a piston able to move in the second chamber to dispense the mixture. The mixing member includes a stem, passing through an opening for dispensing the mixture in the second chamber, having an outer end equipped with a handle and an inner end provided with a mixing blade connected to the inner end with a releasable connection.
