The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0 C temperatures. Also provided are peptoid peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers peptoid peptide hybrids and cryoprotectant solutions provided herein are useful for making antifreeze solutions frozen food products and cosmetic care products. Also provided herein are methods for preserving a tissue an organ a cell or a biological macromolecule using the compositions described herein.
