6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS

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专利权人:

SANOFI

发明人:

BOUABOULA, Monsif,BROLLO, Maurice,CERTAL, Victor,EL-AHMAD, Youssef,FILOCHE-ROMMÉ, Bruno,HALLEY, Frank,MCCORT, Gary,SCHIO, Laurent,TABART, Michel,TERRIER, Corinne,THOMPSON, Fabienne

申请号：

SG11201806829T

公开号：

SG11201806829TA

申请日:

2017.02.14

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The present invention relates to processes and intermediates for the preparation of compounds of formula (I):wherein R1 and R2 represent hydrogen or deuterium atoms； R3 represents a hydrogen atom or a -COOH, a -OH or a -OPO(OH)group； R4 represents a hydrogen atom or a fluorine atom； R5 represents a hydrogen atom or a -OH group； wherein at least one of R3 or R5 is different from a hydrogen atom； when R3 represents a-COOH, -OH or-OPO(OH)group, then R5 represents a hydrogen atom； when R5 represents a -OH group, then R3 and R4 represent hydrogen atoms； and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl or heterocycloalkyl group.

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