Prospect Chartercare RWMC; LLC d/b/a Roger Williams Medical Center
发明人:
Katz, Steven C.,Junghans, Richard
申请号：
AU2016294602
公开号：
AU2016294602A1
申请日:
2016.07.14
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure provides compositions and methods for treating a peritoneal cancer in a subject. The methods include administering a T cell which is genetically modified to express a chimeric T cell receptor protein. The chimeric T cell receptor protein may include a T cell receptor signaling domain fused to the tumor associated antigen-binding fragment of an antibody or a T cell receptor signaling domain fused to a naturally occurring ligand which specifically binds to a tumor cell surface protein. The compositions and methods disclosed herein are therapeutically effective to reduce, for example, tumor burden, abdominal ascites, peritoneal mucin, or serum tumor marker levels.
