An improved system for safely and accurately placing intracranial catheters by using techniques from the field of artificial intelligence (AI) which combine the output from in vivo ultrasonic sensors with in vivo video cameras and an embedded inertial measurement unit. The AI subsystem synthesis the output from the three sensors to determine an optimal route to the desired intracranial site while avoiding larger blood vessels en route. Additionally, by using the output from the inertial measurement unit, the catheters complete trajectory can be recorded and made available for post-operative analysis. The entire system is portable so that it can be used outside of the hospital operating room, for example, in an intensive care unit. Compared to standard freehand methods of placing intracranial catheters, the system embodied here will reduce concomitant hemorrhaging while increasing the accuracy of catheter placement.